Inflammation & Tissue Damage

A Root Cause or Major Contributing Factor in Many Diseases & Conditions

  • Neuropathy
  • Retinopathy
  • Nephropathy
  • Rheumatoid Arthritis
  • Inflammatory Bowel Disease
  • Wound Healing
  • Cardiovascular Diseases
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The Active Role of the Innate Repair Receptor (IRR) in Inflammation and Tissue Repair

  • The innate repair receptor (IRR) was discovered by Drs Anthony Cerami and Michael Brines while they were attempting to identify the body’s natural mechanism to shut off the production of proinflammatory cytokines.
  • IRR, while not normally present on healthy cells, becomes rapidly expressed in response to inflammation or damage.
  • Following activation, IRR initiates tissue protection via reparative and anti-inflammatory signaling pathways.
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IRR Signaling Suppresses Inflammation and Activates Repair via Multiple Signaling Pathways

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Cibinetide Activates the Innate Repair Receptor

Inflammation With Inadequate Tissue Repair Is a Root Cause or Major Contributing Factor in Many Diseases & Conditions

  • Lead compound of a family of novel peptides targeting chronic diseases and acute conditions
  • A novel, first-in-class, synthetic 11-amino-acid peptide
  • Binds to the innate repair receptor with high affinity and selectivity
  • Activating tissue protection
  • Activating tissue repair
  • Activating anti-inflammatory signaling pathways
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Cibinetide

Efficacy Across a Wide Array of Preclinical Models of Tissue Damage and Repair

Cibinetide Platform Breadth Has Been Investigated by an Extensive Network of Leading Global Academic Experts

Sarcoidosis Daniel Culver Cleveland Clinic
Diabetic Neuropathy Robert Schmidt Washington University School of Medicine
Diabetic Retinopathy Alan Stitt Queen’s University, Belfast
Neuropathy Rayaz Malik Weill Cornell Medicine-Qatar
Pain & Neuropathy Albert Dahan Leiden University Medical Center
Diabetes Claes-Göran Östenson Karolinska Institute
Pain Biomarkers Torsten Gordh Uppsala University
Heart Disease Masanobu Kawakami Jichi Medical University
Aging Edward Lakatta National Institute on Aging
Kidney Injury Christoph Theimermann William Harvey Research Institute
Burn Injury Martin Yarmush Harvard Medical School
Alzheimer’s Disease Michael Bacher University of Marburg
Islet Transplantation Torbjörn Lundgren Karolinska Institute
Traumatic Brain Injury Claudia Robertson Baylor College of Medicine
Epilepsy Nihal de Lanerolle Yale University School of Medicine
Inflammatory Bowel Disease Gunther Weiss Medical University of Innsbruck

Extensive research has resulted in >70 peer-reviewed scientific publications.