Inflammation & Tissue Damage
A Root Cause or Major Contributing Factor in Many Diseases & Conditions
The Active Role of the Innate Repair Receptor (IRR) in Inflammation and Tissue Repair
The innate repair receptor (IRR) was discovered by Drs Anthony Cerami and Michael Brines while they were attempting to identify the body’s natural mechanism to shut off the production of proinflammatory cytokines.
IRR, while not normally present on healthy cells, becomes rapidly expressed in response to inflammation or damage.
Following activation, IRR initiates tissue protection via reparative and anti-inflammatory signaling pathways.
IRR Signaling Suppresses Inflammation and Activates Repair via Multiple Signaling Pathways
ARA 290 Activates the Innate Repair Receptor
Inflammation With Inadequate Tissue Repair Is a Root Cause or Major Contributing Factor in Many Diseases & Conditions
Lead compound of a family of novel peptides targeting chronic diseases and acute conditions
A novel, first-in-class, synthetic 11-amino-acid peptide
Binds to the innate repair receptor with high affinity and selectivity
Efficacy Across a Wide Array of Preclinical Models of Tissue Damage and Repair
ARA 290 Platform Breadth Has Been Investigated by an Extensive Network of Leading Global Academic Experts
||Washington University School of Medicine
||Queen’s University, Belfast
||Weill Cornell Medicine-Qatar
|Pain & Neuropathy
||Leiden University Medical Center
||Jichi Medical University
||National Institute on Aging
||William Harvey Research Institute
||Harvard Medical School
||University of Marburg
|Traumatic Brain Injury
||Baylor College of Medicine
||Nihal de Lanerolle
||Yale University School of Medicine
|Inflammatory Bowel Disease
||Medical University of Innsbruck
Extensive research has resulted in >70 peer-reviewed scientific publications.